Mostrando "Análisis Secundario"
Barbara Cabrejo
ABSTRACT
Introduction: Colorectal cancer (CRC) is the third most common cancer globally and a leading cause of cancer-related deaths. While liver metastasis is common, brain metastasis (BM) is rare, occurring in 0.1% to 14% of cases. Risk factors for BM include lung metastasis at diagnosis, rectal cancer, and mutations in RAS and KRAS genes. Due to its rarity, guidelines for BM screening and treatment are limited. The aim of this study is to identify the clinical characteristics and predictors of BM at the time of the initial diagnosis of CRC. Methods: We evaluated patients ≥18 years old with metastatic colorectal cancer and brain metastases at diagnosis from the SEER database (2010–2021). A retrospective cohort study was conducted to analyze overall survival and predictive factors for brain metastasis, utilizing multivariate logistic regression, Kaplan–Meier survival analysis, and the Cox proportional hazards models, with p-values < 0.05 considered significant. Results: Out of 24,703 patients with metastatic colorectal cancer (mCRC), 228 (0.92%) had brain metastasis (BM) at diagnosis. BM was more prevalent in average-onset mCRC (≥50 years) compared to early-onset (<50 years) (1% vs. 0.55%, p = 0.004). Certain factors, such as older age and adenocarcinoma subtype, were associated with BM. Additionally, Asians/Pacific-Islanders (HR 1.83 CI: 1.01-3-33, p = 0.045) and American Indians/Alaska Natives (HR 4.79 CI 1.15–19.97, p = 0.032) had higher mortality rates, while surgical treatment and chemotherapy were linked to decreased mortality. Patients with BM had significantly worse overall survival (6 months vs. 21 months, p < 0.001). Conclusion: BM in mCRC is uncommon, but it is associated with significantly worse outcomes, including markedly reduced overall survival. Our study highlights several critical factors associated with the presence of BM, such as older age and specific racial/ethnic groups, which may inform risk stratification and early-detection strategies. Our findings emphasize the need for heightened awareness and screening for BM in high-risk mCRC patients, as well as the inclusion of these patients in clinical trials to explore tailored therapeutic approaches aimed at improving survival and quality of life.
NOMBRE DE LA REVISTA
Medical Sciences
TIPO DE MANUSCRITO
Análisis secundario
IDIOMA
Inglés
AUTORES DE LA SOCIEDAD
Jerry K. Benites-Meza
Coral Florian
ABSTRACT
Objetivos: evaluar la asociación entre la edad materna y la presencia de infecciones respiratorias agudas (IRAs) y enfermedades diarreicas agudas (EDAs) en niños peruanos menores de cinco años.
Métodos: análisis secundario de la base de datos de la “Encuesta Demográfica y de Salud Familiar” de 2015 y 2019. Se analizaron datos de niños menores de cinco años y sus madres en edad reproductiva que viven en el mismo hogar. Se utilizaron modelos de regresión de Poisson para calcular razones de prevalencia ajustadas (RPa) con sus intervalos de confianza del 95% (IC95%) para evaluar la asociación entre el grupo de edad de las madres y la presencia de IRAs y EDAs en sus hijos.
Resultados: se analizaron 84,671 datos madre/hijo. En el modelo de regresión ajustado, ser madre joven (RPa= 1,18; IC95%= 1,11-1,25; p<0,001) o adolescente (RPa= 1,11; IC95%= 1,01-1,22; p=0,045) se asoció con una mayor prevalencia de IRAs en sus hijos. Además, ser madre joven (RPa= 1,18; IC95%= 1,11-1,25; p<0,001) o adolescente RPa= 1,22; IC95%= 1,10-1,35; p<0,001 también se asoció con una mayor prevalencia de EDAs en sus hijos.
Conclusiones: la edad de las madres se asoció con la prevalencia de IRAs y EDAs en niños peruanos menores de cinco años, siendo las madres adolescentes y jóvenes las que presentaron mayor probabilidad de IRAs y EDAs.
NOMBRE DE LA REVISTA
Revista Brasileira de Saude Materno Infantil
TIPO DE MANUSCRITO
Análisis secundario
IDIOMA
Español
AUTORES DE LA SOCIEDAD
Jerry K. Benites-Meza
CPPC SOCEMUNT
RESUMEN
We aimed to determine the variations in the prevalence of childhood anemia according to the ethnic group before and during the COVID-19 pandemic in Peru. Secondary analysis of the Demographic and Family Health Survey during 2016-2021. The outcome variable was anemia, and the exposure variable was maternal ethnicity. Also, we included sociodemographic and clinical confounding variables. We constructed generalized linear models of the Poisson family with a logarithmic link function. We evaluated 85,905 records; 30.34% had anemia, 50.83% were mestizo, 25.98% were Quechua, and 2% were Aymara. Compared with mestizos, Quechua children, Aymara , natives of the Amazon and those who belonged to other indigenous peoples (PR: 1.29; 95% CI: 1.05-1.57; p = 0.013) had a higher prevalence of childhood anemia. On the contrary, compared to mestizos, white children had a lower prevalence of anemia (PR: 0.93; 95% CI: 0.89-0.99; p = 0.019). During the COVID-19 pandemic, compared to mestizos, only Quechua and Aymara had a higher prevalence of childhood anemia. Except for Afro-descendants, children from 6 to 59 months of age who belong to an ethnic minority had a higher probability of having childhood anemia than mestizos. However, only Quechua and Aymara children had higher odds of anemia during the COVID-19 pandemic than mestizos.
NOMBRE DE LA REVISTA
Journal of Immigrant and Minority Health
BASE DE DATOS A LA CUAL PERTENECE
Scopus, Pubmed
TIPO DE MANUSCRITO
Artículo original
IDIOMA
Inglés
AUTORES DE LA SOCIEDAD
Jerry K Benites-Meza
CPPC SOCEMUNT
ABSTRACT
Objective: To assess the relationship between the self-perceived consultation time and the knowledge of the proposed treatment.
Methods: Secondary data from a 2015 national survey of health services in Peru were analyzed. The self-perceived consultation time was calculated by asking how long it took from when you entered the consultation until you departed. It was then categorized as low, medium, and high. Five self-reported questions were used to construct a knowledge of the prescribed treatment. Adjusted regression models from the Poisson family models were used to evaluate the relationship. We report adjusted prevalence ratios (aPR) with their 95% confidence intervals (95%CI).
Results: A total of 9939 outpatients were analyzed, with 58% women; the average age was 44 years; and 45.4% had higher education. Using low self-perceived consultation time as references, medium and high consultation times were associated with understanding the prescribed treatment (aPR=1.17; 95%CI, 1.04-1.33 and aPR=1.30; 95%CI, 1.20-1.40, respectively).
Conclusion: Patients who reported a medium and high self-perceived consultation time better understood the prescribed treatment.
Implications for practice: Healthcare professionals should strive to maximize consultation time to ensure effective communication and improve patient knowledge of treatments, improving overall patient satisfaction and health outcomes.
NOMBRE DE LA REVISTA
Patient Education and Counseling
BASE DE DATOS A LA CUAL PERTENECE
Scopus, Pubmed, Embase, Annals of Behavioral Medicine, Health Promotion and Education Database
TIPO DE MANUSCRITO
Artículo original
IDIOMA
Inglés
AUTORES DE LA SOCIEDAD
Jerry K Benites-Meza
CPPC SOCEMUNT
Resumen
We aimed to conduct a scoping review to assess the profile of retracted
health sciences articles authored by individuals affiliated with
academic institutions in Latin America and the Caribbean (LAC). We
systematically searched seven databases (PubMed, Scopus, Web of Science,
Embase, Medline/Ovid, Scielo, and LILACS). We included articles
published in peer-reviewed journals between 2003 and 2022 that had at
least one author with an institutional affiliation in LAC. Data were
collected on the year of publication, study design, authors' countries
of origin, number of authors, subject matter of the manuscript,
scientific journals of publication, retraction characteristics, and
reasons for retraction. We included 147 articles, the majority being
observational studies (41.5%). The LAC countries with the highest number
of retractions were Brazil (n = 69), Colombia (n = 16), and Mexico
(n = 15). The areas of study with the highest number of retractions were
infectology (n = 21) and basic sciences (n = 15). A retraction label was
applied to 89.1% of the articles, 70.7% were retracted by journal
editors, and 89.1% followed international retraction guidelines. The
primary reasons for retraction included errors in procedures or data
collection (n = 39), inconsistency in results or conclusions (n = 37),
plagiarism (n = 21), and suspected scientific fraud (n = 19). In
conclusion, most retractions of scientific publications in health
sciences in LAC adhered to international guidelines and were linked to
methodological issues in execution and scientific misconduct. Efforts
should be directed toward ensuring the integrity of scientific research
in the field of health.
NOMBRE DE LA REVISTA
Developing World Bioethics
BASE DE DATOS A LA CUAL PERTENECE
Sage, EBSCO Publishing, EBSCO Publishing, EBSCO Publishing, Clarivate
Analytics
TIPO DE MANUSCRITO
Scoping review
IDIOMA
Inglés
AUTORES DE LA SOCIEDAD
Jerry K. Benites-Meza
CPPC SOCEMUNT
ABSTRACT
Background: Intimate partner violence (IPV) against women is common
during pregnancy and can have adverse mental health outcomes in women.
Our objective was to evaluate the association between IPV and symptoms
of depression in Peruvian pregnant women. Methods: In this study, we
performed a secondary analysis of the Demographic and Family Health
Survey, ENDES 2013–2019. The study population consisted of a subsample
of married or cohabiting Peruvian pregnant women. IPV was defined as any
reported violence (psychological, physical, or sexual) committed by the
last partner of women. The symptoms of depression were measured using
the Patient Health Questionnaire-9. Poisson regression-generalized
linear models were used to calculate adjusted prevalence ratios (aPR)
with their respective 95% confidence intervals (95% CI). Results:
Overall IPV was 11.64%. The prevalence of psychological, physical, and
sexual IPV was 6.92%, 8.56%, and 1.12%, respectively. After adjusting
for confounding variables, IPV was associated with the symptoms of
depression. Conclusion: One in 10 pregnant women experienced IPV, the
most frequent type being physical violence. One in four pregnant women
experiences depressive disorders. Furthermore, the presence of
psychological, physical, or sexual violence independently doubles the
probability of the occurrence of depression in Peruvian pregnant women.
NOMBRE DE LA REVISTA
Journal of Pharmaceutical Health Services Research
BASE DE DATOS A LA CUAL PERTENECE
Scopus
TIPO DE MANUSCRITO
Artículo original
IDIOMA
Inglés
AUTORES DE LA SOCIEDAD
Jerry K. Benites-Meza
CPPC SOCEMUNT
ABSTRACT
Objectives: To determine the association between self-medication with antibiotics (SMA) and purchase of brand-name drugs in Peru.
Methods: A secondary analysis was conducted using a nationally representative survey from 2014 to 2016. The exposure variable was self-medication (SM), which is defined as the purchase of drugs for self-administration without a medical prescription. The study outcome was the purchase of brand-name drugs (yes/no). Sociodemographic variables, such as health insurance and type of institution, were considered as confounders. To assess the association between SMA and the purchase of brand-name drugs, the crude prevalence ratios (cPR) and adjusted prevalence ratios (aPR) were calculated with their confidence intervals at 95% (95% CI) using a Poisson-type generalized linear model and considering the complex survey design.
Key findings: A total of 1862 participants were analysed; 54.4% of the participants were women with a mean age of 39.3 years. The prevalence rate of SMA was 54.3%, whereas that of the purchase of brand-name drugs was 55.3%. The adjusted Poisson regression analysis showed an association between SMA and the purchase of brand-name drugs (aPR = 1.28; 95% CI: 1.18–1.37; P < 0.001).
Conclusions: It was found that 5 of 10 respondents SMA. Approximately 6 of 10 respondents that SMA used brand-name drugs. SMA is associated with a higher probability of purchasing brand-name drugs.
NOMBRE DE LA REVISTA
Embase, ESCI, Scopus
BASE DE DATOS A LA CUAL PERTENECE
Pubmed, Scopus, Web of Science, EBSCO
TIPO DE MANUSCRITO
Análisis secundario
IDIOMA
Inglés
CPPC SOCEMUNT
RESUMEN
Background: Older adults are a particularly vulnerable group to drug use and self-medication. The aim of the study was to evaluate self-medication as a factor associated with the purchase of brand-name and over-the-counter (OTC) drugs in older adults in Peru.
Methods: A secondary analysis was performed using an analytical cross-sectional design of data from a nationally representative survey from 2014 to 2016. The exposure variable was self-medication, defined as the purchase of medicines without a prescription. The dependent variables were purchases of brand-name and OTC drugs, both as a dichotomous response (yes/no). Information of sociodemographic variables, health insurance, and the types of drugs purchased by the participants was collected. Crude prevalence ratios (PR) were calculated and adjusted using generalized linear models of the Poisson family, considering the complex sample of the survey.
Results: In this study, 1,115 respondents were evaluated, with a mean age of 63.8 years and a male proportion of 48.2%. The prevalence of self-medication was 66.6%, while the proportions of purchases of brand-name and OTC drugs were 62.4% and 23.6%, respectively. The adjusted Poisson regression analysis revealed an association between self-medication and the purchase of brand-name drugs (adjusted PR [aPR]=1.09; 95% confidence interval [CI]: 1.01–1.19). Likewise, self-medication was associated with the purchase of OTC medications (aPR=1.97; 95%CI: 1.55–2.51).
Conclusions: This study evidenced a high prevalence of self-medication in Peruvian older adults. Two-thirds of the surveyed people bought brand-name drugs, whereas one-quarter bought OTC drugs. Self-medication was associated with a greater likelihood of buying brand-name and OTC drugs.
NOMBRE DE LA REVISTA
Canadian Geriatrics Journal
BASE DE DATOS A LA CUAL PERTENECE
Pubmed, Scopus, Web of Science, EBSCO
TIPO DE MANUSCRITO
Análisis Secundario
IDIOMA
Inglés
Coral Florian
ABSTRACT
We aimed to estimate the prevalence and factors
associated with parents’ non-intention to vaccinate their children and
adolescents against COVID-19 in Colombia and Peru. We performed a secondary
analysis using a database generated by the University of Maryland and Facebook
(Facebook, Inc). We Included adult (18 and over) Facebook users residing in LAC
who responded to the survey between May 20, and November 5, 2021. We Included
sociodemographic characteristics, comorbidities, mental health, economic and food
insecurity, compliance with mitigation strategies against COVID-19, and
practices related to vaccination against this disease. We estimated crude (cPR)
and adjusted (aPR) prevalence ratios with their respective 95 %CI. We analyzed
a sample of 44,678 adults from Colombia and 24,302 from Peru. The prevalence of
parents' non-intention to vaccinate their children and adolescents against
COVID-19 was 7.41 % (n = 3,274) for Colombia and 6.64 % (n = 1,464) for Peru.
In Colombia, age above 35 years old, compliance with physical distancing, use
of masks, having economic insecurity, anxiety symptoms, having a chronic
condition or more comorbidities, and being vaccinated were associated with a
higher probability of vaccinating children and adolescents against COVID-19. In
Peru, female gender, compliance with physical distancing, use of masks, having
economic insecurity, anxiety symptoms, having a chronic condition or more
comorbidities, having had COVID-19, and being vaccinated were associated with a
higher probability of vaccinating children against COVID-19. Living in a town,
a village, or a rural area was associated with a higher prevalence of
non-intention to vaccinate children and adolescents against COVID-19. About 9
out of 10 parents in Colombia and Peru intend to vaccinate their children and
adolescents against COVID-19. This intention is associated with some factors
which are similar between the two countries, as well as other factors and
variations among the different regions of each country.
NOMBRE DE LA REVISTA
Vaccine: X
BASE DE DATOS A LA CUAL PERTENECE
Embase, Scopus, DOA, Web of Science, PubMed Central
TIPO DE MANUSCRITO
Análisis Secundario
IDIOMA
English
AUTORES DE LA SOCIEDAD
Jerry K. Benites Meza
Coral Florian
Resumen
Users of complementary and alternative medicine (CAM) have a lower intention to receive vaccines. Furthermore, Latin America and the Caribbean (LAC) region are among the most affected areas by the COVID-19 pandemics and present a high proportion of CAM users. Therefore, this study evaluates the association between the consumption of herbal supplements or homeopathic remedies to prevent COVID-19 and the intention to vaccinate against COVID-19 in the LAC region. We conducted a secondary data analysis of a Massachusetts Institute of Technology (MIT) survey with Facebook to assess COVID-19 beliefs, behaviours, and norms. Crude and adjusted prevalence ratios (aPR) with their respective 95% confidence intervals (95% CI) were calculated using generalized linear models of the Poisson family with the log link function. The prevalence of the use of products to prevent COVID-19 was the following: consumption of herbal supplements (7.2%), use of homeopathic remedies (4.8%), and consumption of garlic, ginger, and lemon (11.8%). An association was found between using herbal supplements (19.0% vs. 12.8%; aPR = 1.44; 95% CI: 1.30–1.58), the use of homeopathic remedies (20.3% vs. 12.3%; aPR = 1.58; 95% CI: 1.25–1.98), and the consumption of garlic, ginger, and lemon (18.9% vs. 11.9%; aPR = 1.55; 95% CI: 1.50–1.61) and non-intention to vaccinate against COVID-19. In the LAC population, there is an association between using herbal supplements, using homeopathic remedies and consuming garlic, ginger, and lemon to prevent infection by COVID-19 and non-intention to vaccinate against this disease. Therefore, it is necessary to design targeted strategies for groups that consume these products as preventive measures against COVID-19 to increase vaccination coverage and expand the information regarding transmission and prevention strategies for SARS-CoV-2.
TITLE
Consumption of Herbal Supplements or Homeopathic Remedies to Prevent COVID-19 and Intention of Vaccination for COVID-19 in Latin America and the Caribbean
NOMBRE DE LA REVISTA
Tropical Medicine and Infectious Disease
BASE DE DATOS A LA CUAL PERTENECE
Scopus, SCIE, PubMed, PMC, Embase, Informit
TIPO DE MANUSCRITO
Artículo original
IDIOMA
English
AUTORES DE LA SOCIEDAD
Jerry K. Benites Meza
